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Stem cells are cells found in all multi cellular organisms. They are characterized by the ability to renew themselves through mitotic cell division and differentiate into a diverse range of specialized cell types. Stem cells can now be grown and transformed into specialized cells with characteristics consistent with cells of various tissues such as muscles or nerves through cell culture. Highly plastic adult stem cells from a variety of sources, including umbilical cord blood and bone marrow, are routinely used in medical therapies. Embryonic cell lines and autologous embryonic stem cells generated through therapeutic cloning have also been proposed as promising candidates for future therapies.
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Stem cell therapy, the hope of healing incurable diseases |
Stem cells are primitive cells not yet differentiated. They can become blood, muscle, nerve, heart and other different systems and organs through differentiation and growth. In recent years, stem cell transplantation has been gradually applied in treatments of end-stage therioma（small cell lung cancer, mammary cancer, ovarian cancer, testicular cancer, neuroblastoma and so on）, heart diseases, nervous system damage, organic tissue repair, diabetes, vascular diseases. Stem cells also have potential to enhance immunity, repair diseased or aging tissue, extend life expectancy, change the human survival state. Therefore, stem cell therapy has inestimable medical value.
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Stem cell research advances in technology, demonstrat great potential in Life Science, especially in clinical applications. Stem cell therapy is to transplant healthy stem cells to patients or their own bodies in order to achieve the repair or reconstruction of diseased cells with normal cells and tissue. Stem cell therapy is a fundamental and effective method of treating many diseases, as to inject new vitality into the body.
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| If you are considering argon-helium knife cryosurgery therapy in China and would like to get know more information about argon-helium knife cryosurgery therapy, please complete the inquiry form or email us hq@1uchina.com |
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Shanghai of Excellence for Stem Cell Therapy |
We have first-class domestic experts in the stem cell therapy and a good combination of funds, global outlook, scientific thinking attitude, which determines the depth of the therapy.
Shanghai hospitals are familiar with the characteristics of stem cell therapy, and have accumulated a great deal of successful experience; relevant sections for stem cell therapy have a more comprehensive understanding, which is conducive to weaken the risk.
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Shanghai has established standard operating procedures (SOP) to ensure the safety and evaluation.
The therapy is illegal in some foreign countries but it is allowed in China.
The cost for therapy is not large, usually save you at least half expenses in your country.
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| If you are considering argon-helium knife cryosurgery therapy in China and would like to get know more information about argon-helium knife cryosurgery therapy, please complete the inquiry form or email us hq@1uchina.com |
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The Clinical Application of Stem Cells in Shanghai |
In recent years, a variety of cell biology including the dendritic cell & cytokine-induced killer cells(DC-CiK);nature killer cells(NKC); CTL; autologous bone marrow mesenchymal stem cells(BMSC) and umbilical cord mesenchymal stem cells(UMSC) have been completed in nearly 500 cases, and cells with stable quality have good clinical safety. Related diseases and patients have gained significant clinical efficacy and benefit.
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| Product |
Features |
Treatment of diseases |
| Autologous bone marrow (BMSC) |
1. Derived from autologous bone marrow, non-medical ethics
2. Easily amplification by culture, suitable for clinical application and production
3. Differentiation to a variety of tissues
4. Supported hematopoiesis |
Ischemic heart disease
Cerebrovascular disease
Peripheral vascular disease
Spinal Cord Injury
Early cirrhosis
Multiple sclerosis
Femoral head necrosis
Repair organs |
| Umbilical cord derived (UMSC) |
1. Derived from umbilical cord tissue, no ethical issues
2. Easily amplification by culture, suitable for clinical application and production
3. Differentiation to a variety of tissues
4. Low immunogenicity
5. Support of hematopoiesis and immune regulation |
Aplastic anemia
GVHD
Diabetes and diabetic foot
others as above
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| Neural stem cells(NSC) |
1. Derived from healthy artificial labor embryos
2. A large number of passages, suitable for clinical application and production
3. Specific for nervous system diseases
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Cerebral palsy
Spinal Cord Injury
Alzheimer's disease
Cerebellar atrophy
Parkinson's disease
Sequelae of stroke
Lateral sclerosis muscular dystrophy |
| Epidermal stem cells(ESC) |
1. Epidermal stem cells specifically
2. Cells in relative naïve & undifferentiated state
3. High proliferative capacity, suitable for clinical application and production |
Diabetic Foot
Wound healing
Anti-aging facial wrinkles |
| Dendritic cells & cytokine induced killer cells(DC-CiK) |
1. Specific tumor cell killing and efficient non-specific tumor suppressor activity
2. Releasing a large number of cytokines
3. Regulating immunity and effectively improving the quality of life
4. Removing small lesions, delaying recurrence and metastasis and prolonging the span of life
5. Enhancing the sensitivity of chemotherapy and the overall therapeutic effect |
Various malignant tumors
Systemic lupus erythematosus
Autoimmune hepatitis |
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Mesenchymal stem cells are pluripotent stem cells. Experimental results show: mesenchymal stem cells differentiate into bone cells, cartilage cells, fat cells, muscle cells, nerve cells and other types of cells. Currently, they have been isolated and cultured from human bone marrow, umbilical cord blood, fat, cartilage, liver and other tissues. The cells can be treated with multiple cells loss or functional disorders through autologous transplantation.
- Keratonosus
- Ischemic heart disease
- Lower limb ischemia
- Orthopedics
- Nervous system disease
- Skin beauty
- Liver
- Tumor
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Human Retinal Pigment Epithelial Cells |
The cells derived from adult eye retinal pigment epithelium, are the best ones in treatment of Parkinson's disease. Although the cells are allogeneic, but experiments show that transplant into the head will not lead to immune rejection. The cell should be transplanted into a suitable target through precise stereotactic brain orientation operation. We have developed a specific tracer, which can observe by PET imaging whether the cell is survival, takes effect or not.
- Parkinson's disease
- Proliferative vitreoretinopathy，PVR
- Age-related macular degeneration，ARMD
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Neural Stem Cells are a kind of pluripotent stem cells, which can differentiate three kinds of primary cells into nervous system, including neurons, glial cells and oligodendrocytes. The cells can get from human neural tissue. We also have developed the method of getting neural stem cells from autologous brain tissue for autologous neural stem cell therapy.
- Acute Spinal Cord Injmy, ASCI
- Cerebral embolism
- Post-traumatic brain syndro
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Some procedures performed at Shanghai hospitals of Excellence for Stem Cell Therapy |
Hepatitis B
10 characteristics stem cell therapy of liver disease
- Specificity - Specializing in hepatitis B virus (HBV).
- Target tropism - DC, installed navigation system, plays a role of T lymphocytes with target to have high accuracy.
- Go-aheadsim - When transfused, active DC cells induced specific CTL response in vivo actively.
- Highly active - Initiatively search and attack HBV.
- Omnibearing - Stimulate specific CTL responses; DC cells induce T cells activation and produce immunes CIK.
- Memory - TCL in vivo has memory. It will kill HBV again to prevent infection.
- Longevity - This kind of long-term presence of anti-HBV-specific immune function in vivo can prevent recurrence.
- Individuation – According to the different types of virus genes in patients’ body, analyses individual viral resistance and does targeted treatment.
- Security - It kills HBV specially and safely.
Standard of stem cell therapy curing hepatitis
| Response type |
Improve |
Basic cure |
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| Biochemical response |
Slightly abnormal or normal in ALT levels |
ALT levels returned to normal |
| Virus Response |
50% reduction in HBV-DNA |
HBV-DNA clearance or inhibition < 105cps/ml |
| Virus markers response |
50% reduction in HBV-M |
"E" seroconversion, HBeAg disappeared + anti-HBe production |
| Histological response |
Histological response Liver histological recovery, light-spot of type-B ultrasonic improvement, activity index ≥ 1 |
Significant recovery of liver histological features, activity index of organization compared with pre-therapy fell ≥ 2 points, significant improvement of type-B ultrasonic light-spot |
| Complete response |
Low HBsAg quantitative, consistent with standard of biochemical improvement in viral response |
HBsAg is negative and consistent with biochemical virus response criteria |
TreatmentEffect
Healing:
- Liver function returned to normal, and symptoms disappeared completely.
- Biochip showed HBV-DNA, HBsAg, HBeAg negative.
- Liver fibrosis was inhibited significantly, hepatic tissue recovery, type-B ultrasonic light-spot significantly improved, and returned to normal.
Improvement:
- Liver function is slightly abnormal, and symptoms disappears.
- Biochip shows concentrations of HBV-DNA, HBsAg, HBeAg decrease significantly.
Invalid:
- liver function is abnormal, and symptoms are obvious.
- Biochip shows no significance in decrease or increase of concentrations of HBV-DNA, HBsAg, HBeAg.
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 Stem cells are not fully differentiated and immature cells with the potential function of regeneration of various tissues and organs, which is called "million by cell” in medical community.
From research, the root cause of human aging is that the number of stem cells decreased and the ability of differentiation reduced, so only through transplanting stem cells in vitro to increase the number of stem cells in vivo and restore early-stage quality of stem cells can fundamentally suppress aging and effectively extend the life time.
After transplanting stem cells into the human body, the body will demand, value-added, differentiated a large number of young cells to replace the aging of the cells in vivo, which will make the body regain homeostasis, repair of all the organizations and organs in time and rapid enhancement of body physiological function. With young cells increasing and senile cells decreasing, the body will definitely return to young state. From the differentiation perspective, the sooner the transplantation of stem cells, the stronger the cell differentiation and the faster refresh rates. Thus it can fundamentally change the general senility of human body cells.
In addition, because stem cells can make hypoderm turgor and improve the ability of cell replacement, the skin wrinkles and pigmentation will gradually be reduced. With gradual improvement of the body enginery, people will become relaxed. So transplanted stem cells through restoring the balance and update of body cells to comprehensively improve body enginery, keep people healthy, improve the quality of life and prolong life time.
Precautions:
- No local lesion in surgical site infected.
- Forbidden to take anticoagulant drugs and aspirin a half months before surgery.
- Take physical examination before surgery to ensure their own health, quality in mind and able to correctly regard results of operations, and no serious organ disease, no blood clotting disease, no diabetes and autoimmune diseases and neurological movement disorders.
- Women should avoid preoperative bathing to keep clean during menstrual period as far as possible.
Notes after Surgery:
- Reduce activities as much as possible for recovery and detumescence, but no bed rest.
- Take anti-inflammatory drugs for 3 to 5 days according to medical advice.
- Use elastic bandage as much as possible after half a month of surgery, raise wounded limb to avoid hematoma and help tighten skin
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Some Frequently Asked Questions in Stem Cell Therapy |
Stem cell transplantation has no side effects, if any, including what risks?
So far, stem cell transplantation has not yet led to large side effects or adverse reactions. Only individual patients suffered some resulting from the puncture site in the lumbar pain, mild dizziness, headache and low fever.
What situation of stem cell transplanted in spinal cord injury?
Spinal cord injury is a refractory disease, although the effect of stem cell transplantation for treatment is very good, but also slowly reflected. Because individual states are different, the time and the probability of walking or the exact effect of recovery is uncertain, but most of the effects are significant.
Is it suitable for children suffering cerebral palsy to transplant? What’s the effect? What’s the most appropriate time? Is the younger the better?
Children with cerebral palsy can use stem cell transplantation in the treatment, period of sequela period the shorter the better. Of course, the effect of children is better than adults, because the children’s brains are still in development, and more active and better acceptance of stem cells. With regards to when to do the treatment, it is recommended to submit the check results to medical professionals to decide.
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| If you are considering argon-helium knife cryosurgery therapy in China and would like to get know more information about argon-helium knife cryosurgery therapy, please complete the inquiry form or email us hq@1uchina.com |
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